SLC12A5-Specific antibody
Product Specifications
Background
KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl-cotransporter that is essential for Cl-homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect ~130 kda monomer and ~250 kDa dimer of KKC2 in brain lysate.
Synonyms
Solute carrier family 12 member 5|Electroneutral potassium-chloride cotransporter 2|K-Cl cotransporter 2 (hKCC2) |Neuronal K-Cl cotransporter|SLC12A5|KCC2|KIAA1176
Gene ID
57468
UniProt
Q9H2X9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Solute carrier family 12 (potassium-chloride transporter), member 5
Target
SLC12A5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
126 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
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