SIRT4 antibody

Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase (PubMed:19220062) . Catalyzes more efficiently removal of lipoyl-and biotinyl-than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879) . Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573) . In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed:23663782) . Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782) . Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (PubMed:23746352) . Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD (+) levels (PubMed:24043310, PubMed:20685656) . Down-regulates insulin secretion (By similarity) .

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial|NAD-dependent ADP-ribosyltransferase sirtuin-4|NAD-dependent protein biotinylase sirtuin-4|NAD-dependent protein deacetylase sirtuin-4|Regulatory protein SIR2 homolog 4|SIR2-like protein 4|SIRT4|SIR2L4