SIRT2 antibody

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

NAD-dependent protein deacetylase sirtuin-2|NAD-dependent protein defatty-acylase sirtuin-2|Regulatory protein SIR2 homolog 2|SIR2-like protein 2|SIRT2|SIR2L|SIR2L2