SIRT1 antibody
Product Specifications
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Synonyms
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) |NAD-dependent protein deacylase sirtuin-1|Regulatory protein SIR2 homolog 1|SIR2-like protein 1 (hSIR2) |SirtT1 75 kDa fragment (75SirT1) |SIRT1|SIR2L1
Gene ID
23411
UniProt
Q96EB6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Sirtuin (silent mating type information regulation 2 homolog) 1
Target
SIRT1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Neuroscience, Stem Cells, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IP: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP
Immunogen Sequence
9-219aa
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