SIRT1 antibody

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) |NAD-dependent protein deacylase sirtuin-1|Regulatory protein SIR2 homolog 1|SIR2-like protein 1 (hSIR2) |SirtT1 75 kDa fragment (75SirT1) |SIRT1|SIR2L1