SIGMAR1 antibody
Product Specifications
Background
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration(PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria(By similarity).
Synonyms
Sigma non-opioid intracellular receptor 1|Aging-associated gene 8 protein|SR31747-binding protein (SR-BP)|Sigma 1-type opioid receptor (SIG-1R, Sigma1-receptor, Sigma1R, hSigmaR1)|SIGMAR1|OPRS1|SRBP
Gene ID
10280
UniProt
Q99720
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
sigma non-opioid intracellular receptor 1
Target
SIGMAR1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cardiovascular, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
27 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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