SFPQ antibody
Product Specifications
Background
SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. This antibody is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.
Synonyms
Splicing factor, proline- and glutamine-rich|100 kDa DNA-pairing protein (hPOMp100) |DNA-binding p52/p100 complex, 100 kDa subunit|Polypyrimidine tract-binding protein-associated-splicing factor (PSF, PTB-associated-splicing factor) |SFPQ|PSF
Gene ID
6421
UniProt
P23246
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)
Target
SFPQ
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:1000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
115 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Curated Selection
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