SETDB2 antibody
Product Specifications
Background
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Synonyms
Histone-lysine N-methyltransferase SETDB2|Chronic lymphocytic leukemia deletion region gene 8 protein|Lysine N-methyltransferase 1F|SET domain bifurcated 2|SETDB2|C13orf4|CLLD8|KMT1F
Gene ID
83852
UniProt
Q96T68
Host
Rabbit
Reactivity
Human
Immunogen
SET domain, bifurcated 2
Target
SETDB2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
101 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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