SETD1B antibody
Product Specifications
Background
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
Synonyms
Histone-lysine N-methyltransferase SETD1B|Lysine N-methyltransferase 2G|SET domain-containing protein 1B (hSET1B) |SETD1B|KIAA1076|KMT2G|SET1B
Gene ID
23067
UniProt
Q9UPS6
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
SET domain containing 1B
Target
SETD1B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP, IHC,IF
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
260 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP, IHC, IF
Immunogen Sequence
Peptide (350-459aa)
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