SET antibody
Product Specifications
Background
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT) . This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
Protein SET|HLA-DR-associated protein II|Inhibitor of granzyme A-activated DNase (IGAAD) |PHAPII|Phosphatase 2A inhibitor I2PP2A (I-2PP2A) |Template-activating factor I (TAF-I) |SET
Gene ID
6418
UniProt
Q01105
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
SET nuclear oncogene
Target
SET
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Cell Division and Proliferation, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
160-290aa
Frequently Asked Questions
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