SCNN1A antibody
Product Specifications
Background
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. It has been reported that full-length SCNN1A protein can be cleaved into 65-and 30-kDa fragments.
Synonyms
Amiloride-sensitive sodium channel subunit alpha|Alpha-NaCH|Epithelial Na (+) channel subunit alpha (Alpha-ENaC, ENaCA) |Nonvoltage-gated sodium channel 1 subunit alpha|SCNEA|SCNN1A|SCNN1
Gene ID
6337
UniProt
P37088
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Sodium channel, nonvoltage-gated 1 alpha
Target
SCNN1A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Frequently Asked Questions
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