S100B antibody
Product Specifications
Background
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Synonyms
Protein S100-B|S-100 protein beta chain|S-100 protein subunit beta|S100 calcium-binding protein B|S100B
Gene ID
6285
UniProt
P04271
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
S100 calcium binding protein B
Target
S100B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
11 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Curated Selection
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