RSPO2 antibody
Product Specifications
Background
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.
Synonyms
R-spondin-2|Roof plate-specific spondin-2 (hRspo2) |RSPO2
Gene ID
340419
UniProt
Q6UXX9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
R-spondin 2 homolog
Target
RSPO2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Neuroscience, Cardiovascular
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:3000; IP: 1:500-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
Immunogen Sequence
22-243aa
Curated Selection
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