RING1 antibody
Product Specifications
Background
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group(PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
Synonyms
E3 ubiquitin-protein ligase RING1|Polycomb complex protein RING1|RING finger protein 1|RING-type E3 ubiquitin transferase RING1|Really interesting new gene 1 protein|RING1|RING1A|RNF1
Gene ID
6015
UniProt
Q06587
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
ring finger protein 1
Target
RING1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Stem Cells, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1299995-01 0.02 mg (E-Coli)
Recombinant Dehalococcoides sp. Imidazole glycerol phosphate synthase subunit HisF (hisF)
Ask
View Details MBS1299995-02 0.1 mg (E-Coli)
Recombinant Dehalococcoides sp. Imidazole glycerol phosphate synthase subunit HisF (hisF)
Ask
View Details 
MBS1299995-03 0.02 mg (Yeast)
Recombinant Dehalococcoides sp. Imidazole glycerol phosphate synthase subunit HisF (hisF)
Ask
View Details MBS1299995-04 0.1 mg (Yeast)
Recombinant Dehalococcoides sp. Imidazole glycerol phosphate synthase subunit HisF (hisF)
Ask
View Details MBS1299995-05 0.02 mg (Baculovirus)
Recombinant Dehalococcoides sp. Imidazole glycerol phosphate synthase subunit HisF (hisF)
Ask
View Details