TLR7 agonist 21
TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7 (TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7) . TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections[1].
Product Specifications
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-21.html
Smiles
NC1=NC2=C(C(NCCCC)=N1)N(C=N2)CC3=CC=C(C=C3OC)CN(CC)CC
Molecular Formula
C22H33N7O
Molecular Weight
411.54
References & Citations
[1]Kim M, et al., Design, Synthesis, and Biological Evaluation of New 2,6,7-Substituted Purine Derivatives as Toll-like Receptor 7 Agonists for Intranasal Vaccine Adjuvants. J Med Chem. 2024 Jun 13;67 (11) :9389-9405.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8
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