RBBP8 antibody
Product Specifications
Background
Endonuclease that cooperates with the MRE11-RAD50-NBN(MRN) complex in processing meiotic and mitotic double-strand breaks(DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining(A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.
Synonyms
DNA endonuclease RBBP8|CtBP-interacting protein (CtIP)|Retinoblastoma-binding protein 8 (RBBP-8)|Retinoblastoma-interacting protein and myosin-like (RIM)|Sporulation in the absence of SPO11 protein 2 homolog (SAE2)|RBBP8|CTIP
Gene ID
5932
UniProt
Q99708
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
retinoblastoma binding protein 8
Target
RBBP8
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cell Division and Proliferation, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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