RBBP6 antibody

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome(PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth(By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites(CFSs) in a ZBTB38-and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication(PubMed:24726359).

E3 ubiquitin-protein ligase RBBP6|Proliferation potential-related protein|Protein P2P-R|RING-type E3 ubiquitin transferase RBBP6|Retinoblastoma-binding Q protein 1 (RBQ-1)|Retinoblastoma-binding protein 6|p53-associated cellular protein of testis|RBBP6|P2PR|PACT|RBQ1