RBBP6 antibody
Product Specifications
Background
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979) . May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity) . Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38-and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359) .
Synonyms
E3 ubiquitin-protein ligase RBBP6|Proliferation potential-related protein|Protein P2P-R|RING-type E3 ubiquitin transferase RBBP6|Retinoblastoma-binding Q protein 1 (RBQ-1) |Retinoblastoma-binding protein 6|p53-associated cellular protein of testis|RBBP6|P2PR|PACT|RBQ1
Gene ID
5930
UniProt
Q7Z6E9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Retinoblastoma binding protein 6
Target
RBBP6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
200 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Curated Selection
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