RASGRF1 antibody
Product Specifications
Background
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms
Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1)|Guanine nucleotide-releasing protein (GNRP)|Ras-specific nucleotide exchange factor CDC25|RASGRF1|CDC25|GNRP|GRF1
Gene ID
5923
UniProt
Q13972
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Ras protein-specific guanine nucleotide-releasing factor 1
Target
RASGRF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cell Division and Proliferation, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
145 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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