RAB8A antibody
Product Specifications
Background
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites(AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.
Synonyms
Ras-related protein Rab-8A|Oncogene c-mel|RAB8A|MEL|RAB8
Gene ID
4218
UniProt
P61006
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
RAB8A, member RAS oncogene family
Target
RAB8A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IP
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
24 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
Curated Selection
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