PUF60 antibody
Product Specifications
Background
This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms
Poly(U)-binding-splicing factor PUF60|60 kDa poly(U)-binding-splicing factor|FUSE-binding protein-interacting repressor (FBP-interacting repressor)|Ro-binding protein 1 (RoBP1)|Siah-binding protein 1 (Siah-BP1)|PUF60|FIR|ROBPI|SIAHBP1
Gene ID
22827
UniProt
Q9UHX1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
poly-U binding splicing factor 60KDa
Target
PUF60
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100; IP: 1:20 - 1:50
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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