PTPRS antibody
Product Specifications
Background
Type II a receptor protein tyrosine phosphatases (rPTPσ) are cell surface receptors important for nervous system development, function, and repair.The expression of rPTPσ has previously been reported in b-cells and other target organs for INS although the probes chosen did not permit to distinguish between the splice variants.Proteolytic processing near the transmembrane domain generates an extracellular N-terminal E-domain of 130 kDa and a C-terminal P-domain of approximately 85 kDa of rPTPσ, and the short splice variants rPTPσ 3 and 4 contain an E-domain of 95 kDa (PMID: 16552719) . rPTPσ expression was observed in tissue lysates of the adult mouse sensory-motor cortex and thoracic spinal cord (T8-T10) as a 75-80kDa immunoreactive band (PMID: 19780196) .
Synonyms
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) |Receptor-type tyrosine-protein phosphatase sigma (R-PTP-sigma) |PTPRS
Gene ID
5802
UniProt
Q13332
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein tyrosine phosphatase, receptor type, S
Target
PTPRS
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP, FC
Field of Research
Signal Transduction, Metabolism, Immunology, Developmental biology, Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
75-100 kDa, 220 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP, FC
Immunogen Sequence
1058-1207aa, Extracellular domain
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