PTPN11 antibody
Product Specifications
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Synonyms
Tyrosine-protein phosphatase non-receptor type 11|Protein-tyrosine phosphatase 1D (PTP-1D)|Protein-tyrosine phosphatase 2C (PTP-2C)|SH-PTP2 (SHP-2, Shp2)|SH-PTP3|PTPN11|PTP2C|SHPTP2
Gene ID
5781
UniProt
Q06124
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
protein tyrosine phosphatase, non-receptor type 11
Target
PTPN11
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
71 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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