PTPN11 antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Tyrosine-protein phosphatase non-receptor type 11|Protein-tyrosine phosphatase 1D (PTP-1D) |Protein-tyrosine phosphatase 2C (PTP-2C) |SH-PTP2 (SHP-2, Shp2) |SH-PTP3|PTPN11|PTP2C|SHPTP2