PTBP1 antibody
Product Specifications
Background
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664) . In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806) .
Synonyms
Polypyrimidine tract-binding protein 1 (PTB) |57 kDa RNA-binding protein PPTB-1|Heterogeneous nuclear ribonucleoprotein I (hnRNP I) |PTBP1|PTB
Gene ID
5725
UniProt
P26599
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Polypyrimidine tract binding protein 1
Target
PTBP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
59.6 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF
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