PSME3 antibody
Product Specifications
Background
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination-and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978) .
Synonyms
Proteasome activator complex subunit 3|11S regulator complex subunit gamma (REG-gamma) |Activator of multicatalytic protease subunit 3|Ki nuclear autoantigen|Proteasome activator 28 subunit gamma (PA28g, PA28gamma) |PSME3
Gene ID
10197
UniProt
P61289
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Target
PSME3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Cancer, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
30 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP
Immunogen Sequence
2-254
Curated Selection
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