PSAP antibody

Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase(EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase(EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A(EC 3.1.6.8), GM1 gangliosides by beta-galactosidase(EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A(EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator(EC 3.1.4.12). Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.

Prosaposin|Proactivator polypeptide|Saposin-A Alternative names: Protein A|Saposin-B-Val|Saposin-B Alternative names: Cerebroside sulfate activator (CSAct)|Dispersin|Sphingolipid activator protein 1 (SAP-1)|Sulfatide/GM1 activator|Saposin-C Alternative names: A1 activator|Co-beta-glucosidase|Glucosylceramidase activator|Sphingolipid activator protein 2 (SAP-2)|Saposin-D Alternative names: Component C|Protein C|PSAP|GLBA|SAP1