PRKACB antibody
Product Specifications
Background
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Synonyms
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta)|PRKACB
Gene ID
5567
UniProt
P22694
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
protein kinase, cAMP-dependent, catalytic, beta
Target
PRKACB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Cell Division and Proliferation, Signal Transduction, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46-55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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