PPP1R8 antibody
Product Specifications
Background
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
Synonyms
Nuclear inhibitor of protein phosphatase 1 (NIPP-1)|Protein phosphatase 1 regulatory inhibitor subunit 8|PPP1R8|ARD1|NIPP1
Gene ID
5511
UniProt
Q12972
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
protein phosphatase 1, regulatory (inhibitor) subunit 8
Target
PPP1R8
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF
Field of Research
Neuroscience, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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