PPM1A antibody
Product Specifications
Background
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Synonyms
Protein phosphatase 1A|Protein phosphatase 2C isoform alpha (PP2C-alpha) |Protein phosphatase IA|PPM1A|PPPM1A
Gene ID
5494
UniProt
P35813
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Target
PPM1A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
42 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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