M-PEG11-acid

M-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Product Specifications

CAS Number

[2280998-74-3]

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m-peg11-acid.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O

Molecular Formula

C24H48O13

Molecular Weight

544.63

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Wilfried Braje et al. Macrocyclic mcl-1 inhibitors and methods of use. WO2019035927A1.|[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.