PLCD4 antibody
Product Specifications
Background
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate(PIP2) to generate 2 second messenger molecules diacylglycerol(DAG) and inositol 1,4,5-trisphosphate(IP3). DAG mediates the activation of protein kinase C(PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Synonyms
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4)|Phosphoinositide phospholipase C-delta-4|Phospholipase C-delta-4 (PLC-delta-4)|PLCD4
Gene ID
84812
UniProt
Q9BRC7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
phospholipase C, delta 4
Target
PLCD4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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