PIEZO1 antibody
Product Specifications
Background
Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678) . Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066) . In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035) . Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity) .
Synonyms
Piezo-type mechanosensitive ion channel component 1|Membrane protein induced by beta-amyloid treatment (Mib) |Protein FAM38A|PIEZO1|FAM38A|KIAA0233
Gene ID
9780
UniProt
Q92508
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Family with sequence similarity 38, member A
Target
PIEZO1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB,IHC
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
250 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
2198-2431aa
Curated Selection
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