PIK3R1 antibody
Product Specifications
Background
Phosphatidylinositol 3-kinase (PI3K) plays an important role in the metabolic actions of insulin and is required for adipogenesis. The PI3K pathway has also been identified as an important player in cancer development and progression. The Class IA PI3K heterodimer, which is composed of a P110 catalytic subunit and a P85 regulatory subunit, is activated upon association of the P85 subunit with upstream adaptor proteins or receptor tyrosine kinases. Mutations in PIK3R1 are implicated in cases of breast cancer and associated to SHORT syndrome.
Synonyms
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha) |Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha (PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha) |PIK3R1|GRB1
Gene ID
5295
UniProt
P27986
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Target
PIK3R1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:10000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
85 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
5G0
Tested Applications
ELISA, WB, IHC, IF, IP
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6473164-01 0.1 mL
DUSP5, NT Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3) (MaxLight 750)
Ask
View Details MBS6473164-02 5x 0.1 mL
DUSP5, NT Dual Specificity Protein Phosphatase 5, Dual Specificity Protein Phosphatase hVH3, VH3) (MaxLight 750)
Ask
View Details