PDK1 antibody
Product Specifications
Background
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Synonyms
[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial|Pyruvate dehydrogenase kinase isoform 1 (PDH kinase 1) |PDK1|PDHK1
Gene ID
5163
UniProt
Q15118
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Pyruvate dehydrogenase kinase, isozyme 1
Target
PDK1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IP
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IP
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