NIAD-4
NIAD-4 is a fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD) . NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM[1].
Product Specifications
CAS Number
868592-56-7
UNSPSC
12171500
Hazard Statement
H315, H319, H335
Target
Amyloid-β; Fluorescent Dye
Type
Dye Reagents
Related Pathways
Neuronal Signaling; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/niad-4.html
Purity
99.11
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
N#C/C(C#N)=C/C1=CC=C(C2=CC=C(C3=CC=C(O)C=C3)S2)S1
Molecular Formula
C18H10N2OS2
Molecular Weight
334.43
Precautions
H315, H319, H335
References & Citations
[1]Kenneth T. Cheng, et al. [[5'- (4-Hydroxyphenyl) [2,2’-bithiophen]-5-yl]methylene]-propanedinitrile NIAD-4.|[2]Brandenburg E, et al., Specific in situ discrimination of amyloid fibrils versus α-helical fibres by the fluorophore NIAD-4. Mol Biosyst. 2012 Feb;8 (2) :557-64.|[3]Bae S, et al. Torsion-dependent fluorescence switching of amyloid-binding dye NIAD-4[J]. Chemical Physics Letters, 2015, 633: 109-113.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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