NIAD-4

NIAD-4 is a fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD) . NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM[1].

Product Specifications

CAS Number

[868592-56-7]

UNSPSC

12171500

Hazard Statement

H315, H319, H335

Target

Amyloid-β; Fluorescent Dye

Type

Dye Reagents

Related Pathways

Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/niad-4.html

Purity

99.11

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

N#C/C(C#N)=C/C1=CC=C(C2=CC=C(C3=CC=C(O)C=C3)S2)S1

Molecular Formula

C18H10N2OS2

Molecular Weight

334.43

Precautions

H315, H319, H335

References & Citations

[1]Kenneth T. Cheng, et al. [[5'- (4-Hydroxyphenyl) [2,2’-bithiophen]-5-yl]methylene]-propanedinitrile NIAD-4.|[2]Brandenburg E, et al., Specific in situ discrimination of amyloid fibrils versus α-helical fibres by the fluorophore NIAD-4. Mol Biosyst. 2012 Feb;8 (2) :557-64.|[3]Bae S, et al. Torsion-dependent fluorescence switching of amyloid-binding dye NIAD-4[J]. Chemical Physics Letters, 2015, 633: 109-113.