PARP3 antibody
Product Specifications
Background
Involved in the base excision repair(BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Synonyms
Protein mono-ADP-ribosyltransferase PARP3|ADP-ribosyltransferase diphtheria toxin-like 3 (ARTD3)|DNA ADP-ribosyltransferase PARP3|IRT1|NAD(+) ADP-ribosyltransferase 3 (ADPRT-3)|Poly [ADP-ribose] polymerase 3 (PARP-3, hPARP-3)|Poly[ADP-ribose] synthase 3 (pADPRT-3)|PARP3|ADPRT3|ADPRTL3
Gene ID
10039
UniProt
Q9Y6F1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
poly(ADP-ribose) polymerase family, member 3
Target
PARP3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60-62 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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