PARP3 antibody

Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Protein mono-ADP-ribosyltransferase PARP3|ADP-ribosyltransferase diphtheria toxin-like 3 (ARTD3) |DNA ADP-ribosyltransferase PARP3|IRT1|NAD (+) ADP-ribosyltransferase 3 (ADPRT-3) |Poly [ADP-ribose] polymerase 3 (PARP-3, hPARP-3) |Poly[ADP-ribose] synthase 3 (pADPRT-3) |PARP3|ADPRT3|ADPRTL3