TENT4B antibody
Product Specifications
Background
Catalytic subunit of a TRAMP-like complex which has a poly (A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo (A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) . Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.
Synonyms
Terminal nucleotidyltransferase 4B|Non-canonical poly (A) RNA polymerase PAPD5|PAP-associated domain-containing protein 5|Terminal guanylyltransferase|Terminal uridylyltransferase 3 (TUTase 3) |Topoisomerase-related function protein 4-2 (TRF4-2) |TENT4B|GLD4|PAPD5|TRF4-2|TUT3
Gene ID
64282
UniProt
Q8NDF8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
PAP associated domain containing 5
Target
TENT4B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa, 80 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
Immunogen Sequence
400-465aa
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