PA2G4 antibody
Product Specifications
Background
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor(AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin(HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase(HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs(internal ribosomal entry site)(By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation(By similarity).
Synonyms
Proliferation-associated protein 2G4|Cell cycle protein p38-2G4 homolog (hG4-1)|ErbB3-binding protein 1|PA2G4|EBP1
Gene ID
5036
UniProt
Q9UQ80
Host
Mouse
Reactivity
Human
Immunogen
proliferation-associated 2G4, 38kDa
Target
PA2G4
Clonality
Monoclonal
Isotype
IgG1
Clone
5C6
Applications
ELISA, WB, IHC, IF
Field of Research
Cardiovascular, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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