OSBPL3 antibody
Product Specifications
Background
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324) . Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204) . The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204) . With VAPA, may regulate ER morphology (PubMed:16143324) . Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267) . Binds to phosphoinositides with preference for PI (3,4) P2 and PI (3,4,5) P3 (PubMed:16143324) . Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193) .
Synonyms
Oxysterol-binding protein-related protein 3 (ORP-3, OSBP-related protein 3) |OSBPL3|KIAA0704|ORP3|OSBP3
Gene ID
26031
UniProt
Q9H4L5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Oxysterol binding protein-like 3
Target
OSBPL3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
101 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
370-520aa
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