NUMB antibody
Product Specifications
Background
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Synonyms
Protein numb homolog (h-Numb)|Protein S171|NUMB|C14orf41
Gene ID
8650
UniProt
P49757
Host
Mouse
Reactivity
Human, Mouse
Immunogen
numb homolog(Drosophila)
Target
NUMB
Clonality
Monoclonal
Isotype
IgG2a
Clone
0E11
Applications
ELISA, WB, IHC, IF
Field of Research
Signal Transduction, Cardiovascular, Immunology, Developmental biology, Neuroscience, Stem Cells
Purification
Protein A+G purification
Dilution
WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
68 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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