NUF2 antibody
Product Specifications
Background
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814) . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592) . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020) .
Synonyms
Kinetochore protein Nuf2 (hNuf2, hNuf2R, hsNuf2) |Cell division cycle-associated protein 1|NUF2|CDCA1|NUF2R
Gene ID
83540
UniProt
Q9BZD4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
NUF2, NDC80 kinetochore complex component, homolog
Target
NUF2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
Frequently Asked Questions
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