AI-10-47
AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM[1].
Product Specifications
CAS Number
[1256094-31-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RUNX
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ai-10-47.html
Concentration
10mM
Purity
98.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
Molecular Formula
C13H8F3N3O
Molecular Weight
279.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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