NFE2L2 antibody
Product Specifications
Background
NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress (PMID:14567983) .In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance (PMID:20534738) . Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.
Synonyms
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2, NFE2-related factor 2, Nrf-2) |HEBP1|Nuclear factor, erythroid derived 2, like 2|NFE2L2|NRF2
Gene ID
4780
UniProt
Q16236
Host
Rabbit
Reactivity
Human, Mouse, Rat, Zebrafish
Immunogen
Nuclear factor (erythroid-derived 2) -like 2
Target
NFE2L2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, WB, IHC, FC
Field of Research
Epigenetics, Cancer, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70-100 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IP, WB, IHC, FC
Immunogen Sequence
120-413aa
Curated Selection
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