NR1H2 antibody
Product Specifications
Background
Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) . Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity) . Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920) .
Synonyms
Oxysterols receptor LXR-beta|Liver X receptor beta|Nuclear receptor NER|Nuclear receptor subfamily 1 group H member 2|Ubiquitously-expressed nuclear receptor|NR1H2|LXRB|NER|UNR
Gene ID
7376
UniProt
P55055
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Nuclear receptor subfamily 1, group H, member 2
Target
NR1H2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience, Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa, 40 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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