NOX4 antibody
Product Specifications
Background
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation.
Synonyms
NADPH oxidase 4|Kidney oxidase-1 (KOX-1) |Kidney superoxide-producing NADPH oxidase|Renal NAD (P) H-oxidase|NOX4|RENOX
Gene ID
50507
UniProt
Q9NPH5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
NADPH oxidase 4
Target
NOX4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP, IF, FC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:500-1:2000; IHC: 1:100-1:400; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP, IF, FC
Immunogen Sequence
214-493
Curated Selection
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