NOTCH1 antibody
Product Specifications
Background
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Synonyms
Neurogenic locus notch homolog protein 1 (Notch 1, hN1) |Translocation-associated notch protein TAN-1|Notch 1 extracellular truncation (NEXT) |Notch 1 intracellular domain (NICD) |NOTCH1|TAN1
Gene ID
4851
UniProt
P46531
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Notch gene homolog 1 (Drosophila)
Target
NOTCH1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:100 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
300 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Curated Selection
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