NGEF antibody
Product Specifications
Background
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension (By similarity) .
Synonyms
Ephexin-1|Eph-interacting exchange protein|Neuronal guanine nucleotide exchange factor|NGEF
Gene ID
25791
UniProt
Q8N5V2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Neuronal guanine nucleotide exchange factor
Target
NGEF
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP, IHC
Field of Research
Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
75 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP, IHC
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