NF2 antibody
Product Specifications
Background
Probable regulator of the Hippo/SWH(Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH(Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Synonyms
Merlin|Moesin-ezrin-radixin-like protein|Neurofibromin-2|Schwannomerlin|Schwannomin|NF2|SCH
Gene ID
4771
UniProt
P35240
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
neurofibromin 2(merlin)
Target
NF2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
66-70 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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